UNDERSTANDING THE ROLE OF NZF3 IN THE IMMUNOSUPPRESSIVE EFFECTS OF ANISOMYCIN ON T CELLS

Authors

  • Collino S Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China.
  • Ghisletti P Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China.
  • Nicoli, C Department of Immunobiology, Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China.

Keywords:

Anisomycin, Chemotherapy, Inflammatory Responses, NZF3, siRNA, T cells

Abstract

Anisomycin, a protein synthesis inhibitor with potential chemotherapeutic applications, has been shown to inhibit inflammatory responses and the activation of T cells, reducing its potential anti-cancer effect. NZF3, a transcription factor, on the other hand, enhances inflammation and the expression of proinflammatory genes. This study aimed to investigate the impact of knocking down the NZF3 gene in T cells on the immunosuppressive effects of anisomycin. The study employed a method for knocking down NZF3 using siRNA in T cells. Results indicated that the knockdown of the NZF3 gene partially reversed the immunosuppressive effects induced by anisomycin. Specifically, colony formation, CD69, CD25, and CD71 expression, and secretion of pro-inflammatory cytokines were increased. These findings suggest that NZF3 may be a potential target to optimize the use of anisomycin for cancer treatment and provide new insight into combination therapies utilizing anisomycin

Published

2023-08-03

How to Cite

Collino , S., Ghisletti , P., & Nicoli, C. (2023). UNDERSTANDING THE ROLE OF NZF3 IN THE IMMUNOSUPPRESSIVE EFFECTS OF ANISOMYCIN ON T CELLS . International Journal of Interdisciplinary Research in Medical and Health Sciences (IJIRMHS), 10(1), 34–38. Retrieved from https://sadijournals.org/index.php/IJIRMHS/article/view/109

Issue

Vol. 10 No. 1 (2023): January-March

Section

Review Paper
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