HAEMOSTATIC DISTURBANCES IN MALARIA-INFECTED PATIENTS FROM SEMI-URBAN MALARIA ENDEMIC AREAS
Keywords:
Malaria, Haemostatic, Platelets, Prothrombin, Thromboplastin, Infection.Abstract
Malaria a mosquito-borne protozoon infection is one of the health challenges facing majority of people living in sub-Sahara Africa including Nigeria (an endemic region). The causative agents Plasmodium species parasitizes host erythrocytes and destroys its hemoglobin thereby causing anaemia in some of the infected individuals. This study evaluated some haemostatic parameters of malaria parasitized subjects living in Owo-Ondo State. Haemostatic parameters (Prothrombin time (PT), Activated Partial Thromboplastin Time (APTT) and Platelet count) in 100 subjects, including 50 malaria-infected and 50 non-malarias infected, living in Owo-Ondo State, an area of malaria mesoendemic transmission in Nigeria were evaluated using standard operating procedure. There was a significant prolongation in PT and APTT in among the symptomatic group compared to the asymptomatic group (p< 0.05). There was a statistically significant decrease (p< 0.05) in the platelet counts of the symptomatic group compared to the asymptomatic group. Subjects infected with malaria parasites exhibited significant changes in some haemostatic parameters, thus inclusion of these parameters in malaria diagnosis could aid in patients’ treatment
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References
Abro, A.H., Saleh, A.A., Abdou, A.S., Ustadi, A.M., Shuri, M. and Seliem, R.M., 2009. Thrombocytopenia in adults with acute malaria. RMJ, 34(2), pp.170-172.
Adeosun, O.G., Oduola, T., Akanji, B.O., Sunday, A.M., Udoh, S.J. and Bello, I.S., 2007. Biochemical alteration in Nigerian children with acute falciparum malaria. African Journal of Biotechnology, 6(7). pp. 881–885
Alho, R.M., Machado, K.V.A., Val, F.F., Fraiji, N.A., Alexandre, M.A., Melo, G.C., Recht, J., Siqueira, A.M., Monteiro, W.M. and Lacerda, M.V., 2017. Alternative transmission routes in the malaria elimination era: an overview of transfusion-transmitted malaria in the
Americas. Malaria journal, 16(1), pp.1-14.
https://doi.org/10.1186/s12936-017-1726-y
Al Karsani, M.S. and Ali, M.S.M., 2009. Haematological Changes In Malaria Infected Blood Stored In Blood Bank Refrigerator (1-6° C). Journal of Science and Technology, 10(1), pp.1-11.
Allain, J. P. (2010). Malaria and transfusion: A neglected subject coming back to the forefront. In Clinical Infectious Diseases 51(10), pp. 1199–1200. https://doi.org/10.1086/656807
Al-Salahy, M., Shnawa, B., Abed, G., Mandour, A. and Al-Ezzi, A., 2016. Parasitaemia and Its Relation to Hematological Parameters and Liver Function among Patients Malaria in Abs, Hajjah, Northwest Yemen. Interdisciplinary Perspectives on Infectious Diseases, 2016, pp.5954394-5954394. https://doi.org/10.1155/2016/5954394
Biggam, A.G., 1929. Malignant malaria associated with the administration of heroin intravenously. Transactions of The Royal Society of Tropical Medicine and Hygiene, 23(2), pp.147-153. https://doi.org/10.1016/S0035-9203(29)90473-9
Bilal, J.A., Malik, E.E., Al-Nafeesah, A. and Adam, I., 2020. Global prevalence of congenital malaria: A systematic review and meta-analysis. European Journal of Obstetrics & Gynecology and Reproductive Biology, 252, pp.534-542. https://doi.org/10.1016/j.ejogrb.2020.06.025
Chau, T.T.H., Mai, N.T.H., Phu, N.H., Luxemburger, C., Chuong, L.V., Loc, P.P., Trang, T.T.M., Vinh, H., Cuong, B.M., Waller, D.J. and Sinh, D.X., 2002. Malaria in injection drug abusers in Vietnam. Clinical infectious diseases, 34(10), pp.1317-1322. https://doi.org/10.1086/340053
Cheesbrough, M. 2006. District Laboratory Practice in Tropical countries, part 1, Cambridge Low price Edition. Pp. 248-250. Cambridge University Press
Cohee, L. and Laufer, M., 2018. Tackling malaria transmission in sub-Saharan Africa. The Lancet Global Health, 6(6), pp.e598e599. https://doi.org/10.1016/S2214-109X(18)30197-9
Dace, J. and Lewis, S., 2001. Basic Haematological techniques.
In Practical haematology 9th edition. Edited by Barbara JB,
Mitchell LS, Imelda B. London:, pp 487-490. Churchill Livingstone
Erel, O., Vural, H., Aksoy, N., Aslan, G. and Ulukanligil, M., 2001. Oxidative stress of platelets and thrombocytopenia in patients with vivax malaria. Clinical biochemistry, 34(4), pp.341-344.
Erhabor, O., Abdulrahaman, A. and Erhabor, T., 2020. Effects of malaria parasitaemia on some haemostatic parameters among pregnant women of African descent in Specialist
Hospital Sokoto, Nigeria. Human Antibodies, 28(1), pp.21-28. https://doi.org/10.3233/HAB-190389
Facer CA (1994). Hematological aspects of malaria. In: Infection and hematology. Oxford:, pp. 259-294. Butterworht Heinmann ltd
Franklinos, L.H., Jones, K.E., Redding, D.W. and Abubakar, I., 2019.
The effect of global change on mosquito-borne disease. The Lancet
Infectious Diseases, 19(9), pp.e302-e312.
https://doi.org/10.1016/S1473-3099(19)30161-6
Gupta, P., Guddattu, V. and Saravu, K., 2019. Characterization of platelet count and platelet indices and their potential role to predict severity in malaria. Pathogens and global health, 113(2), pp.8693.https://doi.org/10.1080/20477724.2019.1600855
Horstmann, R.D. and Dietrich, M., 1985. Haemostatic alterations in malaria correlate to parasitaemia. Blut, 51(5), pp.329-335.
Khan, S.J., Khan, F.R., Usman, M. and Zahid, S., 2008. Malaria can lead to Thrombocytopenia. Rawal Medical Journal, 33(2), pp.183185.
Kayode, O.T., Kayode, A.A.A. and Awonuga, O.O., 2011. Status of selected hematological and biochemical parameters in malaria and malaria-typhoid co-infection. Journal of Biological Sciences, 11(5), pp.367-373. https://doi.org/10.3923/jbs.2011.367.373
Lillicrap, D., Key, N., Makris, M. and O’Shaughnessy, D. 2009. Practical Hemostsis and Thrombosis.. Pp. 1-5. Wiley-Blackwell
London School of Hygiene & Tropical Medicine. 2021. The Global Challenge of Vector-Borne Diseases and How to Control Them |
LSHTM. Retrieved June 4, 2021, from
https://www.lshtm.ac.uk/study/courses/short-courses/free-onlinecourses/vector-borne-diseases
Maina, R.N., Walsh, D., Gaddy, C., Hongo, G., Waitumbi, J., Otieno, L., Jones, D. and Ogutu, B.R., 2010. Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malaria journal, 9(3), pp.1-11.
https://doi.org/10.1186/1475-2875-9-S3-S4
Miller, L.H., Baruch, D.I., Marsh, K. and Doumbo, O.K., 2002. The pathogenic basis of malaria. Nature, 415(6872), pp.673-679.
Minard, G., Touche, S., Delavelle, A.C., Bonnet, M., Huguenin, A. and
N’Guyen, Y., 2020. Case Report: Could Artemisinin-Based Combination Therapy Prevent Occupational Malaria following Blood Exposure?. The American Journal of Tropical Medicine and
Hygiene, 104(1), pp.240-242. https://doi.org/10.4269/AJTMH.20-
Mohapatra, S., Samantaray, J.C., Arulselvi, S. and Ghosh, A., 2013. Disseminated intravascular coagulation following malaria due to Plasmodium vivax: a thromboelastography-based study. Malaria journal, 12(1), pp.1-4. doi:10.1186/1475-2875-12-336
National Population Commission, 2007: 2006 Population and housing
Census Enumerator’s Manual. Federal Republic of Nigeria, Abuja Nigeria. https://www.nationalpopulation.gov.n
Oladimeji, K.E., Tsoka-Gwegweni, J.M., Ojewole, E. and Yunga, S.T., 2019. Knowledge of malaria prevention among pregnant women and non-pregnant mothers of children aged under 5 years in Ibadan, South West Nigeria. Malaria journal, 18(1), pp.1-12.
https://doi.org/10.1186/s12936-019-2706-1
Olupot-Olupot, P., Eregu, E.I., Naizuli, K., Ikiror, J., Acom, L. and Burgoine, K., 2018. Neonatal and congenital malaria: a case series in malaria endemic eastern Uganda. Malaria journal, 17(1), pp.1-5.. https://doi.org/10.1186/s12936-018-2327-0
Omer, S.A., Adam, I., Noureldien, A., Elhaj, H., Guerrero-Latorre, L., Silgado, A., Sulleiro, E. and Molina, I., 2020. Congenital Malaria in Newborns Delivered to Mothers with Malaria-Infected Placenta in
Blue Nile State, Sudan. Journal of tropical pediatrics, 66(4), pp.428-
. https://doi.org/10.1093/TROPEJ/FMZ083
Osaro, E., Jamilu, M.H., Ahmed, H. and Ezimah, A., 2014. Effect of plasmodium Parasitaemia on some haematological parameters in children living in Sokoto, North Western, Nigeria. International Journal of Clinical Medicine Research, 1(2), pp.57-64. http://www.aascit.org/journal/ijcmr
Owusu-Ofori, A.K., Parry, C. and Bates, I., 2010. Transfusiontransmitted malaria in countries where malaria is endemic: a review of the literature from sub-Saharan Africa. Clinical
Infectious Diseases, 51(10), pp.1192-1198.
https://doi.org/10.1086/656806
Oyibo, W., Ntadom, G., Uhomoibhi, P., Oresanya, O., Ogbulafor, N., Ajumobi, O., Okoh, F., Maxwell, K., Ezeiru, S., Nwokolo, E. and Amajoh, C., 2021. Geographical and temporal variation in reduction of malaria infection among children under 5 years of age throughout Nigeria. BMJ global health, 6(2), p.e004250. https://doi.org/10.1136/bmjgh-2020-004250
Peprah, S., Ogwang, M.D., Kerchan, P., Reynolds, S.J., Tenge, C.N., Were, P.A., Kuremu, R.T., Wekesa, W.N., Masalu, N., Kawira, E. and Kinyera, T., 2020. Mean platelet counts are relatively decreased with malaria but relatively increased with endemic Burkitt Lymphoma in Uganda, Tanzania, and Kenya. British journal of haematology, 190(5), pp.772-782. https://doi.org/10.1111/bjh.16700
Percário, S., Moreira, D.R., Gomes, B.A., Ferreira, M.E., Gonçalves, A.C.M., Laurindo, P.S., Vilhena, T.C., Dolabela, M.F. and Green, M.D., 2012. Oxidative stress in malaria. International journal of molecular sciences, 13(12), pp.1634616372.
Ramalho-Ortigao, M., & Gubler, D. J. (2020). Human Diseases Associated With Vectors (Arthropods in Disease
Transmission). In Hunter’s Tropical Medicine and Emerging Infectious Diseases pp. 1063–1069. Elsevier.
https://doi.org/10.1016/b978-0-323-55512-8.00147-2
Ramnik S (2009). Medical Laboratory Technology Methods and Interpretations 6th edition, Jaypee Brother Medical Publishers Ltd, New Delhi, pp380-383. Jaypee Brother Medical Publishers Ltd, New Delhi
Rowe, J.A., Claessens, A., Corrigan, R.A. and Arman, M., 2009. Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. Expert Reviews in Molecular Medicine, 11(e16), pp.26-2009.doi:10.1017/S1462399409001082
Sakzabre, D., Asiamah, E.A., Akorsu, E.E., Abaka-Yawson, A., Dika, N.D., Kwasie, D.A., Ativi, E., Tseyiboe, C. and Osei, G.Y., 2020. Haematological Profile of Adults with Malaria Parasitaemia Visiting the Volta Regional Hospital, Ghana. Advances in Hematology, 2020, pp.9369758-9369758. https://doi.org/10.1155/2020/9369758
Sotimehin, S.A., Runsewe-Abiodun, T.I., Oladapo, O.T., Njokanma, O.F. and Olanrewaju, D.M., 2008. Possible risk factors for congenital malaria at a tertiary care hospital in Sagamu, Ogun State, South-West Nigeria. Journal of Tropical
Pediatrics, 54(5), pp.313-320.
https://doi.org/10.1093/tropej/fmn016
Squire, D.S., Asmah, R.H., Brown, C.A., Adjei, D.N., ObengNkrumah, N. and Ayeh-Kumi, P.F., 2016. Effect of Plasmodium falciparum malaria parasites on haematological parameters in Ghanaian children. Journal of parasitic diseases, 40(2), pp.303-311. https://doi.org/10.1007/S12639-
-0501-Z
Weir, W., 1997. Two cases of malaria: four messages. Weekly releases (1997–2007), 1(12),
p.1077.https://doi.org/10.2807/esw.01.12.01077-en
Wells, M.B. and Andrew, D.J., 2019. Anopheles salivary gland architecture shapes plasmodium sporozoite availability for transmission. mBio, 10(4), pp.e01238-19. https://doi.org/10.1128/mBio
Wickramasinghe, S.N. and Abdalla, S.H., 2000. Blood and bone marrow changes in malaria. Best Practice & Research Clinical Haematology, 13(2), pp.277-299.
https://doi.org/10.1053/beha.1999.0072
World Health Organization. 2020. Vector-borne diseases. https://www.who.int/news-room/fact-sheets/detail/vector-bornediseases (accessed 4th June 2021)
World Health Organization. (2021). Malaria. 2021. https://www.who.int/news-room/fact-sheets/detail/malaria (accessed 3rd June 2021)
