PHENYLETHYL RESORCINOL LOADED IN LIPID NANO VESICLES: A PROMISING WHITENING COSMETIC INGREDIENT

Abstract

This study aimed to develop a delivery system using lipid nano vesicles (LNVs) for the whitening cosmetic ingredient phenylethyl resorcinol (PR) which has high tyrosinase inhibitory ability but suffers from poor water solubility and photostability. PR-loaded LNVs (PR-LNVs) were prepared and characterized for their physical and chemical features, including morphology, particle size, encapsulation efficiency, and stability. The PR-LNVs showed a homogeneous spherical morphology with a mean particle size of 132.4 nm and high encapsulation efficiency of 97.37%. Moreover, the PR-LNVs demonstrated sustained-release properties and physicochemical stability for at least three months. The results suggest the promising potential of PR-LNVs as a delivery vehicle for phenylethyl resorcinol in cosmetics. This study highlights the significance of nanocarrier technology in improving the efficacy of cosmetics and overcoming the limitations faced by poorly soluble and unstable cosmetic ingredients, such as PR. Furthermore, LNVs' small particle size, high encapsulation efficiency, good stability, and promotion of transdermal absorption suggest their potential as a delivery system for other active ingredients in cosmetics