ROLE OF NANOPARTICLES IN THE EFFICACY OF ANTIBIOTICS

Abstract

Now a day, the reason of greater mortality rate is due to bacterial diseases. The cure of bacterial
diseases is the use of antibiotics but there is a problem that bacteria have become multidrug resistant and so
antibiotics can’t be used for treating bacterial diseases. A great revolution in this aspect is the use of
nanoparticles. Nanoparticles can be made from different metals like gold, copper, zinc etc. The mode of action
of nanoparticles is that they enter into the cell membrane of pathogen and affect their molecular pathways.
Nanoparticles are used in combination with different drugs. The nanoparticles which have been extensively
studied are silver nanoparticles. Experiments were performed of check the efficiency of silver nanoparticles
in gram positive and gram negative bacteria. Silver nanoparticles were not used with the combination of any
drug. Nanoparticles are stable for long time as they are surrounded by capping layers because of which they
are stable for long time. Another important function of these capping layers is that they are also providing
active surface area for the interaction with other biological components. Shortly, we can say that nanoparticles
can be used as an alternative to antibiotics and they can serve us in better way.