ADENOMYOSIS MICE EXHIBIT INHIBITED ERΑ PROTEIN EXPRESSION AND CELL PROLIFERATION BY XAV-939

Authors

  • Liu S Department of Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou 510632, China
  • Fan W Wanqun Chen, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China.

Keywords:

Adenomyosis, XAV-939, Wnt/β-catenin signaling pathway, ERα, cell proliferation

Abstract

Adenomyosis is a gynecological disease in which the endometrial glands and stroma invade into the myometrium leading to symptoms such as pain, abnormal bleeding, and infertility. The pathophysiology of adenomyosis is not well understood, but estrogen is known to play a role. In this study, we investigated the use of XAV-939, an inhibitor of the Wnt/β-catenin signaling pathway, in the treatment of adenomyosis. We established an adenomyosis disease model in mice and treated them with XAV-939 by intraperitoneal injection. We found that XAV-939 inhibited the expression of ERα, a subtype of estrogen receptors known to induce the development of adenomyosis, and suppressed cell proliferation in the adenomyotic cells. Our results suggest that XAV-939 could be a potential treatment option for adenomyosis.

Published

2023-08-02

How to Cite

Liu, S., & Fan, W. (2023). ADENOMYOSIS MICE EXHIBIT INHIBITED ERΑ PROTEIN EXPRESSION AND CELL PROLIFERATION BY XAV-939 . Interdisciplinary Journal of Agriculture and Environmental Sciences (IJAES), 9(2), 13–18. Retrieved from https://sadijournals.org/index.php/IJAES/article/view/39

Issue

Vol. 9 No. 2 (2022): April-June

Section

Original Peer Reviewed Articles
Copyright & Licensing